Filamins

A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.

Also Known As:

280 kDa Actin-Binding Protein; Filamin; Filamin 1; Filamin 1-Like Protein; Filamin A; Filamin B; Filamin C; Merofilamins; alpha-Filamin; beta-Filamin; 1-Like Protein, Filamin; 1-Like Proteins, Filamin; 280 kDa Actin Binding Protein; Cs, Filamin; Filamin 1 Like Protein; Filamin 1-Like Proteins; Filamin Cs; Merofilamin; Protein, Filamin 1-Like; Proteins, Filamin 1-Like; alpha Filamin; alpha-Filamins; beta Filamin; beta-Filamins

Cells
- Cellular Structures
  - Intracellular Space
    - Cytoplasm
      - Cytoplasmic Structures
        Cytoskeleton
        Actin Cytoskeleton
        Filamins: 593
Macromolecular Substances: 97
- Polymers: 13529
  - Biopolymers: 836
    - Microfilament Proteins: 501
      - Filamins: 593
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Cytoskeletal Proteins: 743
    - Microfilament Proteins: 501
      - Filamins: 593
  - Contractile Proteins: 703
    - Filamins: 593

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Disease

Drug/Important Bio-Agent (IBA)